May 2020

  • Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension. Hodgson J, Swietlik EM, Salmon RM, Hadinnapola C, Nikolic I, Wharton J, Guo J, Liley J, Haimel M, Bleda M, Southgate L, Machado RD, Martin JM, Treacy CM, Yates K, Daugherty LC, Shamardina O, Whitehorn D, Holden S, Bogaard HJ, Church C, Coghlan G, Condliffe R, Corris PA, Danesino C, Eyries M, Gall H, Ghio S, Ghofrani HA, Gibbs JSR, Girerd B, Houweling AC, Howard L, Humbert M, Kiely DG, Kovacs G, Lawrie A, MacKenzie Ross RV, Moledina S, Montani D, Olschewski A, Olschewski H, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Prokopenko I, Rhodes CJ, Scelsi L, Seeger W, Soubrier F, Suntharalingam J, Toshner MR, Trembath RC, Vonk Noordegraaf A, Wort SJ, Wilkins MR, Yu PB, Li W, Gräf S, Upton PD, Morrell NW. Am J Respir Crit Care Med. 2020 Mar 1;201(5):575-585. doi: 10.1164/rccm.201906-1141OC.
  • Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing. Sommer N, Alebrahimdehkordi N, Pak O, Knoepp F, Strielkov I, Scheibe S, Dufour E, Andjelković A, Sydykov A, Saraji A, Petrovic A, Quanz K, Hecker M, Kumar M, Wahl J, Kraut S, Seeger W, Schermuly RT, Ghofrani HA, Ramser K, Braun T, Jacobs HT, Weissmann N, Szibor M. Sci Adv. 2020 Apr 15;6(16):eaba0694. doi: 10.1126/sciadv.aba0694. eCollection 2020 Apr.
  • Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract. Sidhwani P, Leerberg DM, Boezio GLM, Capasso TL, Yang H, Chi NC, Roman BL, Stainier DYR, Yelon D. Development. 2020 May 21. pii: dev.185900. doi: 10.1242/dev.185900. [Epub ahead of print]
  • Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles. Sreenivasan K, Ianni A, Künne C, Strilic B, Günther S, Perdiguero E, Krüger M, Spuler S, Offermanns S, Gómez-Del Arco P, Redondo JM, Munoz-Canoves P, Kim J, Braun T. Cell Rep. 2020 May 19;31(7):107652. doi: 10.1016/j.celrep.2020.107652.
  • QTc interval evaluation in patients with right bundle branch block or bifascicular blocks. Erkapic D, Frommeyer G, Brettner N, Sözener K, Crijns HJGM, Seyfarth M, Hamm CW, Bogossian H. Clin Cardiol. 2020 May 19. doi: 10.1002/clc.23389. [Epub ahead of print]
  • Dynamics of cerebral oxygenation during rapid ventricular pacing and its impact on outcome in transfemoral transcatheter aortic valve implantation. Seppelt PC, Mas-Peiro S, De Rosa R, Murray IM, Arsalan M, Holzer L, Lotz G, Meybohm P, Zacharowski K, Walther T, Zeiher AM, Fichtlscherer S, Vasa-Nicotera M. Catheter Cardiovasc Interv. 2020 May 20. doi: 10.1002/ccd.28975. [Epub ahead of print]
  • UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells. Schömel N, Gruber L, Alexopoulos SJ, Trautmann S, Olzomer EM, Byrne FL, Hoehn KL, Gurke R, Thomas D, Ferreirós N, Geisslinger G, Wegner MS. Sci Rep. 2020 May 18;10(1):8182. doi: 10.1038/s41598-020-65182-y.
  • Synthesis of Stable NAD+ Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitinating Enzyme SdeC. van der Heden van Noort G, Madern JM, Kim RQ, Misra M, Dikic I, Zhang Y, Ovaa H, Codee JDC, Filippov DV. Chembiochem. 2020 May 18. doi: 10.1002/cbic.202000230. [Epub ahead of print]
  • Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles. Sreenivasan K, Ianni A, Künne C, Strilic B, Günther S, Perdiguero E, Krüger M, Spuler S, Offermanns S, Gómez-Del Arco P, Redondo JM, Munoz-Canoves P, Kim J, Braun T. Cell Rep. 2020 May 19;31(7):107652. doi: 10.1016/j.celrep.2020.107652.
  • Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing. Sommer N, Alebrahimdehkordi N, Pak O, Knoepp F, Strielkov I, Scheibe S, Dufour E, Andjelković A, Sydykov A, Saraji A, Petrovic A, Quanz K, Hecker M, Kumar M, Wahl J, Kraut S, Seeger W, Schermuly RT, Ghofrani HA, Ramser K, Braun T, Jacobs HT, Weissmann N, Szibor M. Sci Adv. 2020 Apr 15;6(16):eaba0694. doi: 10.1126/sciadv.aba0694. eCollection 2020 Apr.
  • Dynamics of cerebral oxygenation during rapid ventricular pacing and its impact on outcome in transfemoral transcatheter aortic valve implantation. Seppelt PC, Mas-Peiro S, De Rosa R, Murray IM, Arsalan M, Holzer L, Lotz G, Meybohm P, Zacharowski K, Walther T, Zeiher AM, Fichtlscherer S, Vasa-Nicotera M. Catheter Cardiovasc Interv. 2020 May 20. doi: 10.1002/ccd.28975. [Epub ahead of print]
  • Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts. Nicin L, Abplanalp WT, Mellentin H, Kattih B, Tombor L, John D, Schmitto JD, Heineke J, Emrich F, Arsalan M, Holubec T, Walther T, Zeiher AM, Dimmeler S. Eur Heart J. 2020 May 14;41(19):1804-1806. doi: 10.1093/eurheartj/ehaa311. No abstract available.
  • Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy. Roedig H, Nastase MV, Wygrecka M, Schaefer L. FEBS J. 2019 Aug;286(15):2965-2979. doi: 10.1111/febs.14791. Epub 2019 Feb 27. Review.
  • TEPIC 2-an extended framework for transcription factor binding prediction and integrative epigenomic analysis. Schmidt F, Kern F, Ebert P, Baumgarten N, Schulz MH. Bioinformatics. 2019 May 1;35(9):1608-1609. doi: 10.1093/bioinformatics/bty856.
  • A comprehensive echocardiographic method for risk stratification in pulmonary arterial hypertension. Ghio S, Mercurio V, Fortuni F, Forfia PR, Gall H, Ghofrani A, Mathai SC, Mazurek JA, Mukherjee M, Richter M, Scelsi L, Hassoun PM, Tello K; TAPSE in PAH investigators (full list in appendix). Eur Respir J. 2020 May 19. pii: 2000513. doi: 10.1183/13993003.00513-2020. [Epub ahead of print]
  • Pulmonary Hypertension in Adults with Congenital Heart Disease: Real-World Data from the International COMPERA-CHD Registry. Kaemmerer H, Gorenflo M, Huscher D, Pittrow D, Apitz C, Baumgartner H, Berger F, Bruch L, Brunnemer E, Budts W, Claussen M, Coghlan G, Dähnert I, D’Alto M, Delcroix M, Distler O, Dittrich S, Dumitrescu D, Ewert R, Faehling M, Germund I, Ghofrani HA, Grohé C, Grossekreymborg K, Halank M, Hansmann G, Harzheim D, Nemes A, Havasi K, Held M, Hoeper MM, Hofbeck M, Hohenfrost-Schmidt W, Jurevičienė E, Gumbienè L, Kabitz HJ, Klose H, Köhler T, Konstantinides S, Köestenberger M, Kozlik-Feldmann R, Kramer HH, Kropf-Sanchen C, Lammers A, Lange T, Meyn P, Miera O, Milger-Kneidinger K, Neidenbach R, Neurohr C, Opitz C, Perings C, Remppis BA, Riemekasten G, Scelsi L, Scholtz W, Simkova I, Skowasch D, Skride A, Stähler G, Stiller B, Tsangaris I, Vizza CD, Noordegraaf AV, Wilkens H, Wirtz H, Diller GP, Grünig E, Rosenkranz S. J Clin Med. 2020 May 13;9(5). pii: E1456. doi: 10.3390/jcm9051456.
  • Dynamics of cerebral oxygenation during rapid ventricular pacing and its impact on outcome in transfemoral transcatheter aortic valve implantation. Seppelt PC, Mas-Peiro S, De Rosa R, Murray IM, Arsalan M, Holzer L, Lotz G, Meybohm P, Zacharowski K, Walther T, Zeiher AM, Fichtlscherer S, Vasa-Nicotera M. Catheter Cardiovasc Interv. 2020 May 20. doi: 10.1002/ccd.28975. [Epub ahead of print]
  • Value of prognostic nutritional index for survival prediction in trans-catheter aortic valve replacement compared to other common nutritional indexes. Mas-Peiro S, Hoffmann J, Seppelt PC, De Rosa R, Murray MI, Walther T, Zeiher AM, Fichtlscherer S, Vasa-Nicotera M. Acta Cardiol. 2020 May 12:1-8. doi: 10.1080/00015385.2020.1757854. [Epub ahead of print]
  • New developments in transcatheter therapy of mitral valve disease. Walther C, Fichtlscherer S, Holubec T, Vasa-Nicotera M, Arsalan M, Walther T. J Thorac Dis. 2020 Apr;12(4):1728-1739. doi: 10.21037/jtd.2019.12.137. Review.
  • Current issues in transcatheter aortic valve replacement. Mas-Peiro S, Fichtlscherer S, Walther C, Vasa-Nicotera M. J Thorac Dis. 2020 Apr;12(4):1665-1680. doi: 10.21037/jtd.2020.01.10. Review.
  • Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, Honoré E, Offermanns S. Nat Commun. 2020 May 8;11(1):2303. doi: 10.1038/s41467-020-16026-w
  • Cost-Effectiveness of Alirocumab in Patients With Acute Coronary Syndromes: The ODYSSEY OUTCOMES Trial. Bhatt DL, Briggs AH, Reed SD, Annemans L, Szarek M, Bittner VA, Diaz R, Goodman SG, Harrington RA, Higuchi K, Joulain F, Jukema JW, Li QH, Mahaffey KW, Sanchez RJ, Roe MT, Lopes RD, White HD, Zeiher AM, Schwartz GG, Gabriel Steg P; ODYSSEY OUTCOMES Investigators. J Am Coll Cardiol. 2020 May 12;75(18):2297-2308. doi: 10.1016/j.jacc.2020.03.029.
  • Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning. Giricz Z, Makkos A, Schreckenberg R, Pöling J, Lörchner H, Kiss K, Bencsik P, Braun T, Schulz R, Ferdinandy P, Schlüter KD. Int J Mol Sci. 2020 May 9;21(9). pii: E3359. doi: 10.3390/ijms21093359.
  • Proteomics of SARS-CoV-2-infected host cells reveals therapy targets. Bojkova D, Klann K, Koch B, Widera M, Krause D, Ciesek S, Cinatl J, Münch C. Nature. 2020 May 14. doi: 10.1038/s41586-020-2332-7. [Epub ahead of print]
  • Value of prognostic nutritional index for survival prediction in trans-catheter aortic valve replacement compared to other common nutritional indexes. Mas-Peiro S, Hoffmann J, Seppelt PC, De Rosa R, Murray MI, Walther T, Zeiher AM, Fichtlscherer S, Vasa-Nicotera M. Acta Cardiol. 2020 May 12:1-8. doi: 10.1080/00015385.2020.1757854. [Epub ahead of print]
  • New developments in transcatheter therapy of mitral valve disease. Walther C, Fichtlscherer S, Holubec T, Vasa-Nicotera M, Arsalan M, Walther T. J Thorac Dis. 2020 Apr;12(4):1728-1739. doi: 10.21037/jtd.2019.12.137. Review.
  • Cardiomyocyte ageing and cardioprotection: Consensus Document from the ESC Working Groups Cell Biology of the Heart and Myocardial Function. Ruiz-Meana M, Bou-Teen D, Ferdinandy P, Gyongyosi M, Pesce M, Perrino C, Schulz R, Sluijter J, Tocchetti CG, Thum T, Madonna R. Cardiovasc Res. 2020 May 8. pii: cvaa132. doi: 10.1093/cvr/cvaa132. [Epub ahead of print]
  • The role of mitochondrial reactive oxygen species, NO and H<sub>2</sub> S in ischaemia/reperfusion injury and cardioprotection. Andreadou I, Schulz R, Papapetropoulos A, Turan B, Ytrehus K, Ferdinandy P, Daiber A, Di Lisa F. J Cell Mol Med. 2020 May 8. doi: 10.1111/jcmm.15279. [Epub ahead of print] Review.
  • Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, Honoré E, Offermanns S. Nat Commun. 2020 May 8;11(1):2303. doi: 10.1038/s41467-020-16026-w.
  • Bauer P, Kraushaar L, Dorr O, Nef H, Hamm CW Most A. Workload-indexed blood pressure response to a maximum exercise test among professional indoor athletes. Eur J Prev Cardiol:2047487320922043, 2020.
  • Blum L, Geisslinger G, Parnham MJ, Grunweller A Schiffmann S. Natural antiviral compound silvestrol modulates human monocyte-derived macrophages and dendritic cells. J Cell Mol Med, 2020.
  • Blum L, Gul S, Ulshofer T, Henke M, Krieg R, Berneburg I, Thomas D, Trautmann S, Kurz J, Geyer J, Geisslinger G, Becker K, Parnham MJ Schiffmann S. In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o. Sci Rep 10:7534, 2020.
  • Daiber A, Kroller-Schon S, Oelze M, Hahad O, Li H, Schulz R, Steven S Munzel T. Oxidative stress and inflammation contribute to traffic noise-induced vascular and cerebral dysfunction via uncoupling of nitric oxide synthases. Redox Biol:101506, 2020. review
  • Hofmeister A, Thomassen MC, Markert S, Marquardt A, Preussner M, Russwurm M, Schermuly RT, Steinhoff U, Grone HJ, Hoyer J, Humphreys BD Grgic I. Development of a new macrophage-specific TRAP mouse (Mac(TRAP)) and definition of the renal macrophage translational signature. Sci Rep 10:7519, 2020.
  • Lang J, Patyna S, Buttner S, Weiler H, Geiger H, Hauser I, Vasa-Nicotera M, Zeiher AM, Fichtlscherer S Honold J. Incidence, risk factors and prognostic impact of acute kidney injury after coronary angiography and intervention in kidney transplant recipients: a single-center retrospective analysis. Postepy Kardiol Interwencyjnej 16:58-64, 2020.
  • Petersen A, Kutsche HS, Nippert F, Schreckenberg R, Schulz R Schluter KD. Induction of Proteasome Subunit Low Molecular Weight Protein (LMP)-2 Is Required to Induce Active Remodeling in Adult Rat Ventricular Cardiomyocytes. Med Sci (Basel) 8, 2020.
  • Stein M, Dohmen H, Wolk B, Eberle F, Kolodziej M, Acker T, Uhl E Jensen A. Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields. Front Oncol 10:477, 2020.
  • Thompson AaR, Wilkins MR, Wild JM, Kiely DG Lawrie A. Editorial: Pulmonary Hypertension: Mechanisms and Management, History and Future. Front Med (Lausanne) 7:125, 2020. editorial
  • Zhang X, Zegar T, Lucas A, Morrison-Smith C, Knox T, French CA, Knapp S, Muller S Siveke JT. Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma. Oncogene, 2020.
  • Enculescu M, Braun S, Thonta Setty S, Busch A, Zarnack K, Konig J Legewie S. Exon Definition Facilitates Reliable Control of Alternative Splicing in the RON Proto-Oncogene. Biophys J 118:2027-2041, 2020.
  • Karunanithi S, Oruganti V, De Wijn R, Drews F, Cheaib M, Nordstrom K, Simon M Schulz MH. Feeding exogenous dsRNA interferes with endogenous sRNA accumulation in Paramecium. DNA Res, 2020.
  • Key J, Maletzko A, Kohli A, Gispert S, Torres-Odio S, Wittig I, Heidler J, Barcena C, Lopez-Otin C, Lei Y, West AP, Munch C Auburger G. Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease. Neurogenetics, 2020.
  • Rhodes CJ, Otero-Nunez P, Wharton J, Swietlik EM, Kariotis S, Harbaum L, Dunning MJ, Elinoff JM, Errington N, Thomson AaR, Iremonger J, Coghlan JG, Corris PA, Howard LS, Kiely DG, Church C, Pepke-Zaba J, Toshner M, Wort SJ, Desai AA, Humbert M, Nichols WC, Southgate L, Tregouet DA, Trembath RC, Prokopenko I, Graf S, Morrell NW, Wang D, Lawrie A Wilkins MR. Whole Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome. Am J Respir Crit Care Med, 2020.
  • Schmitt J, Mathew S, Doerr O Hamm CW. The wearable cardioverter-defibrillator in acute coronary syndromes, a distinctive point of view. Europace, 2020.
  • Steven S, Frenis K, Kalinovic S, Kvandova M, Oelze M, Helmstadter J, Hahad O, Filippou K, Kus K, Trevisan C, Schluter KD, Boengler K, Chlopicki S, Frauenknecht K, Schulz R, Sorensen M, Daiber A, Kroller-Schon S Munzel T. Exacerbation of adverse cardiovascular effects of aircraft noise in an animal model of arterial hypertension. Redox Biol:101515, 2020.
  • Trembinski DJ, Bink DI, Theodorou K, Sommer J, Fischer A, Van Bergen A, Kuo CC, Costa IG, Schurmann C, Leisegang MS, Brandes RP, Alekseeva T, Brill B, Wietelmann A, Johnson CN, Spring-Connell A, Kaulich M, Werfel S, Engelhardt S, Hirt MN, Yorgan K, Eschenhagen T, Kirchhof L, Hofmann P, Jae N, Wittig I, Hamdani N, Bischof C, Krishnan J, Houtkooper RH, Dimmeler S Boon RA. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Nat Commun 11:2039, 2020.
  • Van Den Bos E, Ambrosy B, Horsthemke M, Walbaum S, Bachg AC, Wettschureck N, Innamorati G, Wilkie TM Hanley PJ. Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor-mediated chemotaxis. J Biol Chem, 2020.
  • Volz C, Breid S, Selenz C, Zaplatina A, Golfmann K, Meder L, Dietlein F, Borchmann S, Chatterjee S, Siobal M, Schottle J, Florin A, Koker M, Nill M, Ozretic L, Uhlenbrock N, Smith S, Buttner R, Miao H, Wang B, Reinhardt HC, Rauh D, Hallek M, Acker-Palmer A, Heukamp LC Ullrich RT. Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC. Cell Rep 31:107568, 2020.
  • Yogeswaran A, Richter MJ, Sommer N, Ghofrani HA, Seeger W, Gall H Tello K. Evaluation of pulmonary hypertension by right heart catheterisation – does timing matter? Eur Respir J, 2020. letter