January 2021

• Berger BT, Amaral M, Kokh DB, Nunes-Alves A, Musil D, Heinrich T, Schröder M, Neil R, Wang J, Navratilova I, Bomke J, Elkins JM, Müller S, Frech M, Wade RC,Knapp S. Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2. Cell Chem Biol, 2021.
• Boengler K, Rohrbach S, Weissmann N,Schulz R. Importance of Cx43 for Right Ventricular Function. Int J Mol Sci 22, 2021. review
• Goetz MJ, Kremer S, Behnke J, Staude B, Shahzad T, Holzfurtner L, Chao CM, Morty RE, Bellusci S,Ehrhardt H. MSC Based Therapies to Prevent or Treat BPD-A Narrative Review on Advances and Ongoing Challenges. Int J Mol Sci 22, 2021. review
• Huard A, Do HN, Frank AC, Sirait-Fischer E, Fuhrmann D, Hofmann MCJ, Raue R, Palmer G, Brüne B, De Bruin N,Weigert A. IL-38 Ablation Reduces Local Inflammation and Disease Severity in Experimental Autoimmune Encephalomyelitis. J Immunol, 2021.
• Ianni A, Kumari P, Tarighi S, Simonet NG, Popescu D, Guenther S, Hölper S, Schmidt A, Smolka C, Yue S, Krüger M, Fiorillo C, Vaquero A, Bober E,Braun T. SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress. Proc Natl Acad Sci U S A 118, 2021.
• Markart P, Drakopanagiotakis F,Wygrecka M. [Antifibrotic therapy – new approvals for non-IPF interstitial lung diseases]. Dtsch Med Wochenschr 146:181-184, 2021.
• Molnár PJ, Dér B, Borsodi K, Balla H, Borbás Z, Molnár K, Ruisanchez É, Kenessey I, Horváth A, Keszthelyi A, Majoros A, Nyirády P, Offermanns S,Benyó Z. Isoprostanes evoke contraction of the murine and human detrusor muscle via activation of the thromboxane prostanoid TP receptor and Rho-kinase. Am J Physiol Renal Physiol, 2021.
• Pham TP, Bink DI, Stanicek L, Van Bergen A, Van Leeuwen E, Tran Y, Matic L, Hedin U, Wittig I, Dimmeler S,Boon RA. Long Non-coding RNA Aerrie Controls DNA Damage Repair via YBX1 to Maintain Endothelial Cell Function. Front Cell Dev Biol 8:619079, 2020.
• Wells CI, Drewry DH, Pickett JE, Tjaden A, Krämer A, Müller S, Gyenis L, Menyhart D, Litchfield DW, Knapp S, Axtman AD. Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chem Biol, 2021.
• Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GM, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, Tansey WP, Verba KA, Vos SM, Weiss WA, Wolf E,Mossé YP. Drugging the ‘undruggable’ MYCN oncogenic transcription factor: Overcoming previous obstacles to impact childhood cancers. Cancer Res, 2021. review
• Zink J, Frye M, Frömel T, Carlantoni C, John D, Schreier D, Weigert A, Laban H, Salinas G, Stingl H, Günther L, Popp R, Hu J, Vanhollebeke B, Schmidt H, Acker-Palmer A, Renné T, Fleming I,Benz PM. EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis. EMBO Rep:e48961, 2021.
• Gubas A, Karantanou C, Popovic D, Tascher G, Hoffmann ME, Platzek A, Dawe N, Dikic I, Krause DS,Mcewan DG. The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways. FEBS Lett, 2021.
• Heger J, Hirschhäuser C, Bornbaum J, Sydykov A, Dempfle A, Schneider A, Braun T, Schlüter KD,Schulz R. Cardiomyocytes-specific deletion of monoamine oxidase B reduces irreversible myocardial ischemia/reperfusion injury. Free Radic Biol Med, 2021.
• Malik AU, Karapetsas A, Nirujogi RS, Mathea S, Chatterjee D, Pal P, Lis P, Taylor M, Purlyte E, Gourlay R, Dorward M, Weidlich S, Toth R, Polinski NK, Knapp S, Tonelli F,Alessi DR. Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms. Biochem J, 2021.
• Mas-Peiro S, Faerber G, Bon D, Herrmann E, Bauer T, Bleiziffer S, Bekeredjian R, Böning A, Frerker C, Beckmann A, Möllmann H, Vasa-Nicotera M, Ensminger S, Hamm CW, Beyersdorf F, Fichtlscherer S,Walther T. Impact of chronic kidney disease in 29 893 patients undergoing transcatheter or surgical aortic valve replacement from the German Aortic Valve Registry. Eur J Cardiothorac Surg, 2021.
• Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, Münch C, Fulda S, Tegeder I,Kögel D. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy:1-20, 2021.
• Nagel E. Why CMR Should Be the Technique of Choice in Patients With Stable Chest Pain. JACC Cardiovasc Imaging, 2021.
• Nieraad H, De Bruin N, Arne O, Hofmann MCJ, Gurke R, Schmidt D, Ritter M, Parnham MJ,Geisslinger G. Effects of Alzheimer-Like Pathology on Homocysteine and Homocysteic Acid Levels-An Exploratory In Vivo Kinetic Study. Int J Mol Sci 22, 2021.
• Rappl P, Brüne B,Schmid T. Role of Tristetraprolin in the Resolution of Inflammation. Biology (Basel) 10, 2021.
• Yilmaz A, Bauersachs J, Bengel F, Büchel R, Kindermann I, Klingel K, Knebel F, Meder B, Morbach C, Nagel E, Schulze-Bahr E, Aus Dem Siepen F,Frey N. Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK). Clin Res Cardiol, 2021.
• Brandes RP, Dueck A, Engelhardt S, Kaulich M, Kupatt C, De Angelis MT, Leisegang MS, Le Noble F, Moretti A, Müller OJ, Skryabin BV, Thum T,Wurst W. DGK and DZHK position paper on genome editing: basic science applications and future perspective. Basic Res Cardiol 116:2, 2021. review
• Brunn D, Turkowski K, Günther S, Weigert A, Muley T, Kriegsmann M, Winter H, Dammann RH, Stathopoulos GT, Thomas M, Guenther A, Grimminger F, Pullamsetti SS, Seeger W,Savai R. Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican. Cancers (Basel) 13, 2021.
• Krauss E, Van Der Beck D, Schmalz I, Wilhelm J, Tello S, Dartsch RC, Mahavadi P, Korfei M, Teschner E, Seeger W,Guenther A. Evaluation of Regional Pulmonary Ventilation in Spontaneously Breathing Patients with Idiopathic Pulmonary Fibrosis (IPF) Employing Electrical Impedance Tomography (EIT): A Pilot Study from the European IPF Registry (eurIPFreg). J Clin Med 10, 2021.
• Lopez M, Malacarne PF, Gajos-Draus A, Ding X, Daiber A, Lundberg JO, Offermanns S, Brandes RP,Rezende F. Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases. Br J Pharmacol, 2021.
• Procida T, Friedrich T, Jack APM, Peritore M, Bönisch C, Eberl HC, Daus N, Kletenkov K, Nist A, Stiewe T, Borggrefe T, Mann M, Bartkuhn M, Hake SB. JAZF1, A Novel p400/TIP60/NuA4 Complex Member, Regulates H2A.Z Acetylation at Regulatory Regions. Int J Mol Sci 22, 2021.
• Segarra M, Aburto MR, Acker-Palmer A. Blood-Brain Barrier Dynamics to Maintain Brain Homeostasis. Trends Neurosci, 2021. review
• Thiele H, Freund A, Gimenez MR, De Waha-Thiele S, Akin I, Pöss J, Feistritzer HJ, Fuernau G, Graf T, Nef H, Hamm C, Böhm M, Lauten A, Schulze PC, Voigt I, Nordbeck P, Felix SB, Abel P, Baldus S, Laufs U, Lenk K, Landmesser U, Skurk C, Pieske B, Tschöpe C, Hennersdorf M, Wengenmayer T, Preusch M, Maier LS, Jung C, Kelm M, Clemmensen P, Westermann D, Seidler T, Schieffer B, Rassaf T, Mahabadi AA, Vasa-Nicotera M, Meincke F, Seyfarth M, Kersten A, Rottbauer W, Boekstegers P, Müllenbach R, Dengler T, Kadel C, Schempf B, Karagiannidis C, Hopf HB, Lehmann R, Bufe A, Baumanns S, Öner A, Linke A, Sedding D, Ferrari M, Bruch L, Goldmann B, John S, Möllmann H, Franz J, Lapp H, Lauten P, Noc M, Goslar T, Oerlecke I, Ouarrak T, Schneider S, Desch S,Zeymer U. Extracorporeal life support in patients with acute myocardial infarction complicated by cardiogenic shock – Design and rationale of the ECLS-SHOCK trial. Am Heart J, 2021.
• Tiku V, Kofoed EM, Yan D, Kang J, Xu M, Reichelt M, Dikic I,Tan MW. Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii. Sci Rep 11:618, 2021.
• Wells CI, Al-Ali H, Andrews DM, Asquith CRM, Axtman AD, Dikic I, Ebner D, Ettmayer P, Fischer C, Frederiksen M, Futrell RE, Gray NS, Hatch SB, Knapp S, Lücking U, Michaelides M, Mills CE, Müller S, Owen D, Picado A, Saikatendu KS, Schröder M, Stolz A, Tellechea M, Turunen BJ, Vilar S, Wang J, Zuercher WJ, Willson TM,Drewry DH. The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. Int J Mol Sci 22, 2021.
• Zhang Z, Wang M, Zhang Y, Zhang Y, Bartkuhn M, Markmann M, Hossain H, Chakraborty T, Hake SB, Jia Z, Meinhardt A,Bhushan S. Uropathogenic Escherichia coli virulence factor α hemolysin reduces histone acetylation to inhibit expression of pro-inflammatory cytokine genes. J Infect Dis, 2021.
• Eul B, Cekay M, Pullamsetti SS, Tello K, Wilhelm J, Gattenlöhner S, Sibelius U, Grimminger F, Seeger W,Savai R. Non-invasive Surrogate Markers of PH are Associated with Poor Survival in Lung Cancer Patients. Am J Respir Crit Care Med, 2021
• Euler G, Locquet F, Kociszewska J, Osygus Y, Heger J, Schreckenberg R, Schlüter KD, Kenyeres É, Szabados T, Bencsik P, Ferdinandy P,Schulz R. Matrix Metalloproteinases Repress Hypertrophic Growth in Cardiac Myocytes. Cardiovasc Drugs Ther, 2021.
• Gaede L, Blumenstein J, Husser O, Liebetrau C, Dörr O, Grothusen C, Eckel C, Al-Terki H, Kim WK, Nef H, Tesche C, Hamm CW, Elsässer A, Achenbach S,Möllmann H. Aortic valve replacement in Germany in 2019. Clin Res Cardiol, 2021.
• Güllülü Ö, Hehlgans S, Mayer BE, Gößner I, Petraki C, Hoffmann M, Dombrowsky MJ, Kunzmann P, Hamacher K, Strebhardt K, Fokas E, Rödel C, Münch C,Rödel F. A spatial and functional interaction of a heterotetramer Survivin-DNA-PKcs complex in DNA damage response. Cancer Res, 2021.
• Landes U, Sathananthan J, Witberg G, De Backer O, Sondergaard L, Abdel-Wahab M, Holzhey D, Kim WK, Hamm C, Buzzatti N, Montorfano M, Ludwig S, Conradi L, Seiffert M, Guerrero M, El Sabbagh A, Rodés-Cabau J, Guimaraes L, Codner P, Okuno T, Pilgrim T, Fiorina C, Colombo A, Mangieri A, Eltchaninoff H, Nombela-Franco L, Van Wiechen MPH, Van Mieghem NM, Tchétché D, Schoels WH, Kullmer M, Tamburino C, Sinning JM, Al-Kassou B, Perlman GY, Danenberg H, Ielasi A, Fraccaro C, Tarantini G, De Marco F, Redwood SR, Lisko JC, Babaliaros VC, Laine M, Nerla R, Castriota F, Finkelstein A, Loewenstein I, Eitan A, Jaffe R, Ruile P, Neumann FJ, Piazza N, Alosaimi H, Sievert H, Sievert K, Russo M, Andreas M, Bunc M, Latib A, Godfrey R, Hildick-Smith D, Chuang MA, Blanke P, Leipsic J, Wood DA, Nazif TM, Kodali S, Barbanti M, Kornowski R, Leon MB,Webb JG. Transcatheter Replacement of Transcatheter Versus Surgically Implanted Aortic Valve Bioprostheses. J Am Coll Cardiol 77:1-14, 2021.
• Mehling R, Schwenck J, Lemberg C, Trautwein C, Zizmare L, Kramer D, Müller A, Fehrenbacher B, Gonzalez-Menendez I, Quintanilla-Martinez L, Schröder K, Brandes RP, Schaller M, Ruf W, Eichner M, Ghoreschi K, Röcken M, Pichler BJ,Kneilling M. Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions. Theranostics 11:470-490, 2021.
• Akhlaghpour A, Taei A, Ghadami SA, Bahadori Z, Yakhkeshi S, Molamohammadi S, Kiani T, Samadian A, Ghezelayagh Z, Haghparast N, Khalooghi K, Braun T, Baharvand H,Hassani SN. Chicken Interspecies Chimerism Unveils Human Pluripotency. Stem Cell Reports, 2020.
• Blessing R, Ahoopai M, Geyer M, Brandt M, Zeiher AM, Münzel T, Wenzel P, Gori T,Dimitriadis Z. The Bioengineered Combo Dual-Therapy CD34 Antibody-Covered Sirolimus-Eluting Coronary Stent in Patients with Chronic Total Occlusion Evaluated by Clinical Outcome and Optical Coherence Tomography Imaging Analysis. J Clin Med 10, 2020.
• Booz C, Vogl TJ, Joseph Schoepf U, Caruso D, Inserra MC, Yel I, Martin SS, Bucher AM, Lenga L, Caudo D, Schreckenbach T, Schoell N, Huegel C, Stratmann J, Vasa-Nicotera M, Rachovitsky-Duarte DE, Laghi A, De Santis D, Mazziotti S, D’angelo T,Albrecht MH. Value of minimum intensity projections for chest CT in COVID-19 patients. Eur J Radiol 135:109478, 2020.
• Guérit S, Fidan E, Macas J, Czupalla CJ, Figueiredo R, Vijikumar A, Yalcin BH, Thom S, Winter P, Gerhardt H, Devraj K,Liebner S. Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance. Prog Neurobiol:101937, 2020.
• Kim WK, Möllmann H, Walther T,Hamm CW. Predictors of permanent pacemaker implantation after ACURATE neo transcatheter heart valve implantation. Pacing Clin Electrophysiol, 2020.
• Kojonazarov B. Heart Rate Reduction by Ivabradine: Slowly but Surely? Am J Respir Cell Mol Biol 63:725-726, 2020.
• Lignelli E, Palumbo F, Bayindir SG, Nagahara N, Vadász I, Herold S, Seeger W,Morty RE. The H(2)S-generating enzyme 3-mercaptopyruvate sulfurtransferase regulates pulmonary vascular smooth muscle cell migration and proliferation but does not impact normal or aberrant lung development. Nitric Oxide 107:31-45, 2020.
• Lüscher TF, Fox K, Hamm C, Carter RE, Taddei S, Simoons M,Crea F. Scientific integrity: what a journal can and cannot do. Eur Heart J 41:4552-4555, 2020.
• Mathew S, Fraebel C, Johnson V, Abdelgwad S, Schneider N, Müller P, Chasan R, Hamm C,Schmitt J. Cardiac arrhythmias in patients with SARS-CoV‑2 infection and effects of the lockdown on invasive rhythmological therapy. Herzschrittmacherther Elektrophysiol:1-6, 2020.
• Moiseenko A, Vazquez-Armendariz AI, Kheirollahi V, Chu X, Tata A, Rivetti S, Günther S, Lebrigand K, Herold S, Braun T, Mari B, De Langhe S, Kwapiszewska G, Günther A, Chen C, Seeger W, Tata PR, Zhang JS, Bellusci S,El Agha E. Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration. Cell Rep 33:108549, 2020.
• Pérez-Bravo D, Myti D, Mižíková I, Pfeffer T, Surate Solaligue DE, Nardiello C, Vadász I, Herold S, Seeger W, Ahlbrecht K,Morty RE. A comparison of airway pressures for inflation fixation of developing mouse lungs for stereological analyses. Histochem Cell Biol, 2020.
• Strack E, Rolfe PA, Fink AF, Bankov K, Schmid T, Solbach C, Savai R, Sha W, Pradel L, Hartmann S, Brüne B,Weigert A. Identification of tumor-associated macrophage subsets that are associated with breast cancer prognosis. Clin Transl Med 10:e239, 2020.
• Wurzlbauer A, Rüben K, Gürdal E, Chaikuad A, Knapp S, Sippl W, Becker W,Bracher F. How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition-The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine. Molecules 25, 2020.
• Alvelos MI, Brüggemann M, Sutandy FR, Juan-Mateu J, Colli ML, Busch A, Lopes M, Castela Â, Aartsma-Rus A, König J, Zarnack K,Eizirik DL. The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells. Life Sci Alliance 4, 2021.
• Schulz R,Wilkins M. Pulmonary hypertension with 2020 vision. Br J Pharmacol 178:3-5, 2021. editorial
• Weferling M, Vietheer J, Keller T, Fischer-Rasokat U, Hamm CW,Liebetrau C. Association Between Primary Coronary Slow-Flow Phenomenon and Epicardial Fat Tissue. J Invasive Cardiol 33:E59-e64, 2021.