February 2022

Blessing RRL, Ahoopai M, Geyer M, Brandt M, Zeiher AM, Vasa-Nicotera M, Münzel T, Wenzel P, Gori T, Dimitriadis Z. Percutaneous coronary intervention for chronic total occlusion in octogenarians: a propensity score study. Sci Rep 12:3073, 2022.
Knoell J, Chillappagari S, Knudsen L, Korfei M, Dartsch R, Jonigk D, Kuehnel MP, Hoetzenecker K, Guenther A, Mahavadi P. PACS2-TRPV1 axis is required for ER-mitochondrial tethering during ER stress and lung fibrosis. Cell Mol Life Sci 79:151, 2022.
Müller N, Warwick T, Noack K, Malacarne PF, Cooper AJL, Weissmann N, Schröder K, Brandes RP, Rezende F. Reactive Oxygen Species Differentially Modulate the Metabolic and Transcriptomic Response of Endothelial Cells. Antioxidants (Basel) 11, 2022.
Müller S, Ackloo S, Al Chawaf A, Al-Lazikani B, Antolin A, Baell JB, Beck H, Beedie S, Betz UaK, Bezerra GA, Brennan PE, Brown D, Brown PJ, Bullock AN, Carter AJ, Chaikuad A, Chaineau M, Ciulli A, Collins I, Dreher J, Drewry D, Edfeldt K, Edwards AM, Egner U, Frye SV, Fuchs SM, Hall MD, Hartung IV, Hillisch A, Hitchcock SH, Homan E, Kannan N, Kiefer JR, Knapp S, Kostic M, Kubicek S, Leach AR, Lindemann S, Marsden BD, Matsui H, Meier JL, Merk D, Michel M, Morgan MR, Mueller-Fahrnow A, Owen DR, Perry BG, Rosenberg SH, Saikatendu KS, Schapira M, Scholten C, Sharma S, Simeonov A, Sundström M, Superti-Furga G, Todd MH, Tredup C, Vedadi M, Von Delft F, Willson TM, Winter GE, Workman P, Arrowsmith CH. Target 2035 – update on the quest for a probe for every protein. RSC Med Chem 13:13-21, 2022. editorial
Peterson BE, Harrington RA, Stone GW, Steg PG, Gibson CM, Hamm CW, Price MJ, Lopes RD, Leonardi S, Prats J, Deliargyris EN, Mahaffey KW, White HD, Bhatt DL. Effect of Platelet Inhibition by Cangrelor Among Obese Patients Undergoing Coronary Stenting: Insights From CHAMPION. Circ Cardiovasc Interv:Circinterventions121011069, 2022.
Roser LA, Erkoc P, Ingelfinger R, Henke M, Ulshöfer T, Schneider AK, Laux V, Geisslinger G, Schmitt I, Fürst R, Schiffmann S. Lecanoric acid mediates anti-proliferative effects by an M phase arrest in colon cancer cells. Biomed Pharmacother 148:112734, 2022.
Salem R, Anantharajah L, Hecker F, Nour-Eldin NEA, Hlavicka J, Walther T, Holubec T. Minimally Invasive Treatment of Kommerell’s Diverticulum and Left Aberrant Subclavian Artery. Ann Thorac Surg, 2022.
Suhrkamp I, Morrison PJ, Assmann JC, Schwaninger M, Wettschureck N, Mrowietz U. ORAL DIMETHYL FUMARATE TARGETS HCA(2)-EXPRESSING SKIN CELLS IN THE IMIQUIMOD MOUSE MODEL. J Invest Dermatol, 2022.
Tjaden A, Chaikuad A, Kowarz E, Marschalek R, Knapp S, Schröder M, Müller S. Image-Based Annotation of Chemogenomic Libraries for Phenotypic Screening. Molecules 27, 2022.
Uenaka M, Yamashita E, Kikuta J, Morimoto A, Ao T, Mizuno H, Furuya M, Hasegawa T, Tsukazaki H, Sudo T, Nishikawa K, Okuzaki D, Motooka D, Kosaka N, Sugihara F, Boettger T, Braun T, Ochiya T, Ishii M. Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo. Nat Commun 13:1066, 2022.
Weidinger A, Birgisdóttir L, Schäffer J, Meszaros AT, Zavadskis S, Müllebner A, Hecker M, Duvigneau JC, Sommer N, Kozlov AV. Systemic Effects of mitoTEMPO upon Lipopolysaccharide Challenge Are Due to Its Antioxidant Part, While Local Effects in the Lung Are Due to Triphenylphosphonium. Antioxidants (Basel) 11, 2022.
Weng JH, Aoto PC, Lorenz R, Wu J, Schmidt SH, Manschwetus JT, Kaila-Sharma P, Silletti S, Mathea S, Chatterjee D, Knapp S, Herberg FW, Taylor SS. LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains. PLoS Biol 20:e3001427, 2022.
Bannow LI, Bonaterra GA, Bertoune M, Maus S, Schulz R, Weissmann N, Kraut S, Kinscherf R, Hildebrandt W. Effect of chronic intermittent hypoxia (CIH) on neuromuscular junctions and mitochondria in slow- and fast-twitch skeletal muscles of mice-the role of iNOS. Skelet Muscle.12:6, 2022.
El-Hindi K, Brachtendorf S, Hartel JC, Oertel S, Birod K, Merz N, Trautmann S, Thomas D, Weigert A, Schäufele TJ, Scholich K, Schiffmann S, Ulshöfer T, Utermöhlen O, Grösch S. T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model. Int J Mol Sci.23, 2022.
El-Nikhely N, Karger A, Sarode P, Singh I, Weigert A, Wietelmann A, Stiewe T, Dammann R, Fink L, Grimminger F, Barreto G, Seeger W, Pullamsetti SS, Rapp UR, Savai R. Correction: Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation. Cancer Res.82:736, 2022. Published erratum
Klann K, Münch C. Quantitative Translation Proteomics Using mePROD. Methods Mol Biol.2428:75-87, 2022.
Martin M, Vermeiren S, Bostaille N, Eubelen M, Spitzer D, Vermeersch M, Profaci CP, Pozuelo E, Toussay X, Raman-Nair J, Tebabi P, America M, De Groote A, Sanderson LE, Cabochette P, Germano RFV, Torres D, Boutry S, de Kerchove d’Exaerde A, Bellefroid EJ, Phoenix TN, Devraj K, Lacoste B, Daneman R, Liebner S, Vanhollebeke B. Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Science.375:eabm4459, 2022.
Olesch C, Brüne B, Weigert A. Keep a Little Fire Burning-The Delicate Balance of Targeting Sphingosine-1-Phosphate in Cancer Immunity. Int J Mol Sci.23, 2022. review
Pappritz K, Lin J, El-Shafeey M, Fechner H, Kühl U, Alogna A, Spillmann F, Elsanhoury A, Schulz R, Tschöpe C, Van Linthout S. Colchicine prevents disease progression in viral myocarditis via modulating the NLRP3 inflammasome in the cardiosplenic axis. ESC Heart Fail. 2022.
Serafim MS, da Silva Santiago A, Schwalm MP, Hu Z, Dos Reis CV, Takarada JE, Mezzomo P, Massirer KB, Kudolo M, Gerstenecker S, Chaikuad A, Zender L, Knapp S, Laufer S, Couñago RM, Gehringer M. Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. J Med Chem. 2022.
Sauerhering L, Kuznetsova I, Kupke A, Meier L, Halwe S, Rohde C, Schmidt J, Morty RE, Danov O, Braun A, Vadász I, Becker S, Herold S. Cyclosporin A Reveals Potent Antiviral Effects in Preclinical Models of SARS-CoV-2 Infection. Am J Respir Crit Care Med. 2022.
Tomaskovic I, Gonzalez A, Dikic I. Ubiquitin and Legionella: From bench to bedside. Semin Cell Dev Biol. 2022. review
Veith C, Vartürk-Özcan I, Wujak M, Hadzic S, Wu CY, Knoepp F, Kraut S, Petrovic A, Gredic M, Pak O, Brosien M, Heimbrodt M, Wilhelm J, Weisel FC, Malkmus K, Schäfer K, Gall H, Tello K, Kosanovic D, Sydykov A, Sarybaev A, Günther A, Brandes RP, Seeger W, Grimminger F, Ghofrani HA, Schermuly RT, Kwapiszewska G, Sommer N, Weissmann N. Secreted Protein Acidic and Rich in Cysteine, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension. Circulation. 2022.
Zhu WF, Krämer A, Knapp S, Proschak E, Hernandez-Olmos V. Cascade Synthesis of Kinase-Privileged 3-Aminoindazoles via Intramolecular N-N Bond Formation. J Org Chem. 2022.
Borsodi K, Balla H, Molnár PJ, Lénárt Á, Kenessey I, Horváth A, Keszthelyi A, Romics M, Majoros A, Nyirády P, Offermanns S, Benyó Z. Signaling Pathways Mediating Bradykinin-Induced Contraction in Murine and Human Detrusor Muscle. Front Med (Lausanne).8:745638, 2021.
Bulinski C, Discher T, Rutsatz W, Assmus B, Krämer HH. Clinical improvement after change of therapy from tafamidis to patisiran in progressive TTR amyloidosis post-liver transplantation. J Neurol. 2022.
Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW. ADAM8 signaling drives neutrophil migration and ARDS severity. JCI Insight.7, 2022.
Heer T, von Scheidt M, Boening A, Heyken C, Gusmini F, de Waha A, Kuna C, Fach A, Grothusen C, Oberhoffer M, Knosalla C, Walther T, Danner BC, Misfeld M, Wimmer-Greinecker G, Siepe M, Grubitzsch H, Joost A, Schaefer A, Conradi L, Cremer J, Hamm C, Lange R, Radke PW, Schulz R, Laufer G, Grieshaber P, Attmann T, Schmoeckel M, Meyer A, Ziegelhöffer T, Hambrecht R, Sandner SE, Kastrati A, Schunkert H, Zeymer U. Prognostic impact of secondary prevention after coronary artery bypass grafting-insights from the TiCAB trial. Eur J Cardiothorac Surg. 2022.
Kahnt AS, Angioni C, Göbel T, Hofmann B, Roos J, Steinbrink SD, Rörsch F, Thomas D, Geisslinger G, Zacharowski K, Grösch S, Steinhilber D, Maier TJ. Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport. Front Pharmacol.12:782584, 2021.
Klann K, Münch C. PBLMM: Peptide-based linear mixed models for differential expression analysis of shotgun proteomics data. J Cell Biochem. 2022.
Kudryashova TV, Dabral S, Nayakanti S, Ray A, Goncharov DA, Avolio T, Shen Y, Rode A, Pena A, Jiang L, Lin D, Baust J, Bachman TN, Graumann J, Ruppert C, Guenther A, Schmoranzer M, Grobs Y, Eve Lemay S, Tremblay E, Breuils-Bonnet S, Boucherat O, Mora AL, DeLisser H, Zhao J, Zhao Y, Bonnet S, Seeger W, Pullamsetti SS, Goncharova EA. Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival. Circ Res.Circresaha121319100, 2022.
Olesch C, Brunn D, Aktay-Cetin Ö, Sirait-Fischer E, Pullamsetti SS, Grimminger F, Seeger W, Brüne B, Weigert A, Savai R. Picturing of the Lung Tumor Cellular Composition by Multispectral Flow Cytometry. Front Immunol.13:827719, 2022.
Umansky C, Morellato AE, Rieckher M, Scheidegger MA, Martinefski MR, Fernández GA, Pak O, Kolesnikova K, Reingruber H, Bollini M, Crossan GP, Sommer N, Monge ME, Schumacher B, Pontel LB. Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity. Nat Commun.13:745, 2022.
Vellecco V, Panza E, Bibli SI, Casillo GM, Raucci F, Manzo OL, Smimmo M, Villani R, Cavezza MR, Fleming I, d’Emmanuele di Villa Bianca R, Maione F, Cirino G, Bucci M. Phosphodiesterases S-sulfhydration contributes to human skeletal muscle function. Pharmacol Res.106108, 2022.
Wedel S, Osthues T, Zimmer B, Angioni C, Geisslinger G, Sisignano M. Oxidized linoleic acid metabolites maintain mechanical and thermal hypersensitivity during sub-chronic inflammatory pain. Biochem Pharmacol.114953, 2022.
Elwakeel E, Brüggemann M, Wagih J, Lityagina O, Elewa MaF, Han Y, Froemel T, Popp R, Nicolas AM, Schreiber Y, Gradhand E, Thomas D, Nüsing R, Steinmetz-Späh J, Savai R, Fokas E, Fleming I, Greten FR, Zarnack K, Brüne B, Weigert A. Disruption of prostaglandin E2 signaling in cancer-associated fibroblasts limits mammary carcinoma growth but promotes metastasis. Cancer Res, 2022.
Klingenberg R, Stähli BE, Heg D, Denegri A, Manka R, Kapos I, Von Eckardstein A, Carballo D, Hamm CW, Vietheer J, Rolf A, Landmesser U, Mach F, Moccetti T, Jung C, Kelm M, Münzel T, Pedrazzini G, Räber L, Windecker S, Matter CM, Ruschitzka F, Lüscher TF. Controlled-Level EVERolimus in Acute Coronary Syndrome (CLEVER-ACS) – A phase II, randomized, double-blind, multi-center, placebo-controlled trial. Am Heart J, 2022.
Kohli A, Sauerhering L, Fehling SK, Klann K, Geiger H, Becker S, Koch B, Baer PC, Strecker T, Münch C. Proteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells. Life Sci Alliance 5, 2022.
Nicolas AM, Pesic M, Engel E, Ziegler PK, Diefenhardt M, Kennel KB, Buettner F, Conche C, Petrocelli V, Elwakeel E, Weigert A, Zinoveva A, Fleischmann M, Häupl B, Karakütük C, Bohnenberger H, Mosa MH, Kaderali L, Gaedcke J, Ghadimi M, Rödel F, Arkan MC, Oellerich T, Rödel C, Fokas E, Greten FR. Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer. Cancer Cell, 2022.
Yin W, Liontos A, Koepke J, Ghoul M, Mazzocchi L, Liu X, Lu C, Wu H, Fysikopoulos A, Sountoulidis A, Seeger W, Ruppert C, Günther A, Stainier DYR, Samakovlis C. An essential function for autocrine Hedgehog signaling in epithelial proliferation and differentiation in the trachea. Development, 2022.

February 2022

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