New this week in PubMed from CPI Institute

  • Ahmadvand N, Khosravi F, Lingampally A, Wasnick R, Vazquez-Armendariz I, Carraro G, Heiner M, Rivetti S, Lv Y, Wilhelm J, Gunther A, Herold S, Al Alam D, Chen C, Minoo P, Zhang JS,Bellusci S. Identification of a novel subset of alveolar type 2 cells enriched in PD-L1 and expanded following pneumonectomy. Eur Respir J, 2021. review

  • Fischer J, Ardakani FB, Kattler K, Walter J,Schulz MH. CpG content-dependent associations between transcription factors and histone modifications. PLoS One 16:e0249985, 2021.

  • Helfinger V, Freiherr Von Gall F, Henke N, Kunze MM, Schmid T, Rezende F, Heidler J, Wittig I, Radeke HH, Marschall V, Anderson K, Shah AM, Fulda S, Brüne B, Brandes RP,Schröder K. Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors. Proc Natl Acad Sci U S A 118, 2021.

  • Ni X, Schröder M, Olieric V, Sharpe ME, Hernandez-Olmos V, Proschak E, Merk D, Knapp S,Chaikuad A. Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain. ACS Med Chem Lett 12:603-609, 2021.

  • Schmitz K, Trautmann S, Hahnefeld L, Fischer C, Schreiber Y, Wilken-Schmitz A, Gurke R, Brunkhorst R, Werner ER, Watschinger K, Wicker S, Thomas D, Geisslinger G,Tegeder I. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Neurotherapeutics, 2021.

  • Tsedeke AT, Allanki S, Gentile A, Jimenez-Amilburu V, Rasouli SJ, Guenther S, Lai SL, Stainier DYR,Marín-Juez R. Cardiomyocyte heterogeneity during zebrafish development and regeneration. Dev Biol, 2021.

  • Weferling M, Liebetrau C, Kraus D, Zierentz P, Von Jeinsen B, Dörr O, Weber M, Nef H, Hamm CW,Keller T. Definition of acute kidney injury impacts prevalence and prognosis in ACS patients undergoing coronary angiography. BMC Cardiovasc Disord 21:183, 2021.

  • Yuan T, Krishnan J. Non-coding RNAs in Cardiac Regeneration. Front Physiol 12:650566, 2021. review

  • Agné A, Richter K, Padberg W, Janciauskiene S,Grau V. Commercial α1-antitrypsin preparations markedly differ in their potential to inhibit the ATP-induced release of monocytic interleukin-1β. Pulm Pharmacol Ther 68:102020, 2021.

  • Andrade J, Shi C, Costa ASH, Choi J, Kim J, Doddaballapur A, Sugino T, Ong YT, Castro M, Zimmermann B, Kaulich M, Guenther S, Wilhelm K, Kubota Y, Braun T, Koh GY, Grosso AR, Frezza C,Potente M. Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol 23:413-423, 2021.

  • Appuhn SV, Siebert S, Myti D, Wrede C, Surate Solaligue DE, Pérez-Bravo D, Brandenberger C, Schipke J, Morty RE, Grothausmann R,Mühlfeld C. Capillary Changes Precede Disordered Alveolarization in a Mouse Model of Bronchopulmonary Dysplasia. Am J Respir Cell Mol Biol, 2021.

  • Bacher S, Meier-Soelch J, Kracht M,Schmitz ML. Regulation of Transcription Factor NF-κB in Its Natural Habitat: The Nucleus. Cells 10, 2021. review

  • Bissen D, Kracht MK, Foss F, Hofmann J,Acker-Palmer A. EphrinB2 and GRIP1 stabilize mushroom spines during denervation-induced homeostatic plasticity. Cell Rep 34:108923, 2021.

  • Geßner A, Koch B, Klann K, Fuhrmann DC, Farmand S, Schubert R, Münch C, Geiger H,Baer PC. Characterization of Extracellular Vesicles from Preconditioned Human Adipose-Derived Stromal/Stem Cells. Int J Mol Sci 22, 2021.

  • Grunddal KV, Tonack S, Egerod KL, Thompson JJ, Petersen N, Engelstoft MS, Vagne C, Keime C, Gradwohl G, Offermanns S,Schwartz TW. Adhesion Receptor Adgrg2/Gpr64 Is In The Gi-Tract Selectively Expressed In Mature Intestinal Tuft Cells. Mol Metab:101231, 2021.

  • Jongejans LL, Liebner S, Knoblauch C, Mangelsdorf K, Ulrich M, Grosse G, Tanski G, Fedorov AN, Konstantinov PY, Windirsch T, Wiedmann J,Strauss J. Greenhouse gas production and lipid biomarker distribution in Yedoma and Alas thermokarst lake sediments in Eastern Siberia. Glob Chang Biol, 2021.

  • Karatas M, Chaikuad A, Berger B, Kubbutat MHG, Totzke F, Knapp S,Kunick C. 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a “Cut and Glue” Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors. Molecules 26, 2021.

  • Kiefer KC, Cremer S, Pardali E, Assmus B, Abou-El-Ardat K, Kirschbaum K, Dorsheimer L, Rasper T, Berkowitsch A, Serve H, Dimmeler S, Zeiher AM,Rieger MA. Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality. ESC Heart Fail, 2021.

  • Kim WK, Doerr O, Renker M, Choi YH, Liakopoulos O, Hamm CW,Nef H. Initial experience with a novel, modular, minimalistic approach for transfemoral aortic valve implantation. Int J Cardiol, 2021.

  • Larrazabal C, Silva LMR, Pervizaj-Oruqaj L, Herold S, Hermosilla C,Taubert A. P-Glycoprotein Inhibitors Differently Affect Toxoplasma gondii, Neospora caninum and Besnoitia besnoiti Proliferation in Bovine Primary Endothelial Cells. Pathogens 10, 2021.

  • Mayer K, Hein-Rothweiler R, Schüpke S, Janisch M, Bernlochner I, Ndrepepa G, Sibbing D, Gori T, Borst O, Holdenrieder S, Kupka D, Petzold T, Bradaric C, Okrojek R, Leistner DM, Trippel TD, Münzel T, Landmesser U, Pieske B, Zeiher AM, Gawaz MP, Hapfelmeier A, Laugwitz KL, Schunkert H, Kastrati A,Massberg S. Efficacy and Safety of Revacept, a Novel Lesion-Directed Competitive Antagonist to Platelet Glycoprotein VI, in Patients Undergoing Elective Percutaneous Coronary Intervention for Stable Ischemic Heart Disease: The Randomized, Double-blind, Placebo-Controlled ISAR-PLASTER Phase 2 Trial. JAMA Cardiol, 2021.

  • Mertens C, Schnetz M, Rehwald C, Grein S, Elwakeel E, Weigert A, Brüne B,Jung M. Iron-Bound Lipocalin-2 from Tumor-Associated Macrophages Drives Breast Cancer Progression Independent of Ferroportin. Metabolites 11, 2021.

  • Mous DS, Buscop-Van Kempen MJ, Wijnen RMH, Tibboel D, Morty RE,Rottier RJ. Opposing Effects of TGFβ and BMP in the Pulmonary Vasculature in Congenital Diaphragmatic Hernia. Front Med (Lausanne) 8:642577, 2021.

  • Pullamsetti SS, Tello K,Seeger W. Utilising biomarkers to predict right heart maladaptive phenotype: a step toward precision medicine. Eur Respir J 57, 2021. editorial

  • Schierle S, Chaikuad A, Lillich FF, Ni X, Woltersdorf S, Schallmayer E, Renelt B, Ronchetti R, Knapp S, Proschak E,Merk D. Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics. J Med Chem, 2021.

  • Vietheer JM, Hamm CW,Rolf A. [Current role of cardiac magnetic resonance (CMR) in diagnosis and therapy of myocardial diseases]. Dtsch Med Wochenschr 146:461-465, 2021.

  • Wack G, Metzner K, Kuth MS, Wang E, Bresnick A, Brandes RP, Schröder K, Wittig I, Schmidtko A,Kallenborn-Gerhardt W. Nox4-dependent upregulation of S100A4 after peripheral nerve injury modulates neuropathic pain processing. Free Radic Biol Med 168:155-167, 2021.

  • Alabed S, Saunders L, Garg P, Shahin Y, Alandejani F, Rolf A, Puntmann VO, Nagel E, Wild JM, Kiely DG, Swift AJ. Myocardial T1-mapping and extracellular volume in pulmonary arterial hypertension: A systematic review and meta-analysis. Magn Reson Imaging.79:66-75, 2021. review
  • Diaz R, Li QH, Bhatt DL, Bittner VA, Baccara-Dinet MT, Goodman SG, Jukema JW, Kimura T, Parkhomenko A, Pordy R, Reiner Ž, Roe MT, Szarek M, Tse HF, White HD, Zahger D, Zeiher AM, Schwartz GG, Steg PG. Intensity of statin treatment after acute coronary syndrome, residual risk, and its modification by alirocumab: insights from the ODYSSEY OUTCOMES trial. Eur J Prev Cardiol.28:33-43, 2021.
  • Hadzic S, Wu CY, Gredic M, Kojonazarov B, Pak O, Kraut S, Sommer N, Kosanovic D, Grimminger F, Schermuly RT, Seeger W, Bellusci S, Weissmann N. The effect of long-term doxycycline treatment in a mouse model of cigarette smoke-induced emphysema and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2021.
  • Hartmann M, Huber J, Kramer JS, Heering J, Pietsch L, Stark H, Odadzic D, Bischoff I, Fürst R, Schröder M, Akutsu M, Chaikuad A, Dötsch V, Knapp S, Biondi RM, Rogov VV, Proschak E. Demonstrating Ligandability of the LC3A and LC3B Adapter Interface. J Med Chem. 2021.
  • Hirschhäuser C, Lissoni A, Görge PM, Lampe PD, Heger J, Schlüter KD, Leybaert L, Schulz R, Boengler K. Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning. Basic Res Cardiol.116:21, 2021.
  • Kim WK, Walther T, Burgdorf C, Möllmann H, Linke A, Redwood S, Thilo C, Hilker M, Joner M, Thiele H, Conzelmann L, Conradi L, Kerber S, Schymik G, Prendergast B, Husser O, Blumenstein J, Stortecky S, Heg D, Künzi A, Jüni P, Windecker S, Pilgrim T, Lanz J. One-Year Outcomes of a Randomized Trial Comparing a Self-Expanding With a Balloon-Expandable Transcatheter Aortic Valve. Circulation.143:1267-1269, 2021.
  • Ni X, Londregan AT, Owen DR, Knapp S, Chaikuad A. Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants. ACS Chem Biol. 2021.
  • Radmanesh F, Sadeghi Abandansari H, Ghanian MH, Pahlavan S, Varzideh F, Yakhkeshi S, Alikhani M, Moradi S, Braun T, Baharvand H. Hydrogel-mediated delivery of microRNA-92a inhibitor polyplex nanoparticles induces localized angiogenesis. Angiogenesis. 2021.
  • Schneck E, Hamm CW, Schneck F, Wolter JS, Dirkmann D, Koch C, Sander M. [Comments on the German consensus statement on prehospital treatment of acute coronary syndrome in patients under long-term treatment with novel oral anticoagulants (NOAC)]. Anaesthesist. 2021. review
  • Vazquez-Armendariz AI, Herold S. From Clones to Buds and Branches: The Use of Lung Organoids to Model Branching Morphogenesis Ex Vivo. Front Cell Dev Biol.9:631579, 2021. review
  • Warwick T, Schulz MH, Günther S, Gilsbach R, Neme A, Carlberg C, Brandes RP, Seuter S. A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes. Sci Rep.11:6518, 2021.

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