New this week in PubMed from CPI Institute

  • Chen J, Sathiaseelan V, Moore AD, Tan S, Chilamakuri CS, Roamio Franklin VN, Shahsavari A, Jakwerth CA, Hake SB, Warren AJ, Mohorianu I, D’Santos CS, Ringshausen I. ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia. Blood. 2021 Feb 22:blood.2020009960. doi: 10.1182/blood.2020009960. Online ahead of print.
  • Risteski P, Bartos O, Miskovic A, Walther T. An Incomplete Form of Shone’s Complex With Double Orifice Mitral Valve. Heart Surg Forum. 2021 Feb 2;24(1):E079-E081. doi: 10.1532/hsf.3239.
  • Němec V, Maier L, Berger BT, Chaikuad A, Drápela S, Souček K, Knapp S, Paruch K. Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core. Eur J Med Chem. 2021 Feb 18;215:113299. doi: 10.1016/j.ejmech.2021.113299. Online ahead of print.
  • Hartmann M, Bibli SI, Tews D, Ni X, Kircher T, Kramer JS, Kilu W, Heering J, Hernandez-Olmos V, Weizel L, Scriba GKE, Krait S, Knapp S, Chaikuad A, Merk D, Fleming I, Fischer-Posovszky P, Proschak E. Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPARγ Modulator. J Med Chem. 2021 Feb 23. doi: 10.1021/acs.jmedchem.0c02063. Online ahead of print.
  • Klann K, Münch C. Den molekularen Wirtszellveränderungen durch SARS-CoV-2 auf der Spur. Biospektrum (Heidelb). 2021;27(1):40-45. doi: 10.1007/s12268-021-1535-3. review
  • Maxeiner J, Sharma R, Amrhein C, Gervais F, Duda M, Ward J, Mikkelsen LF, Forster R, Malewicz M, Krishnan J. Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs. J Pharmacol Toxicol Methods. 2021 Feb 17:106956. doi: 10.1016/j.vascn.2021.106956. Online ahead of print.
  • Wu Y, Wharton J, Walters R, Vasilaki E, Aman J, Zhao L, Wilkins MR, Rhodes CJ. The pathophysiological role of novel pulmonary arterial hypertension gene SOX17. Eur Respir J. 2021 Feb 25:2004172. doi: 10.1183/13993003.04172-2020. Online ahead of print. Review
  • Luxán G, Dimmeler S. The vasculature: a therapeutic target in heart failure? Cardiovasc Res. 2021 Feb 23:cvab047. doi: 10.1093/cvr/cvab047. Online ahead of print.
  • Nicin L, Abplanalp WT, Schänzer A, Sprengel A, John D, Mellentin H, Tombor L, Keuper M, Ullrich E, Klingel K, Dettmeyer RB, Hoffmann J, Akintuerk H, Jux C, Schranz D, Zeiher AM, Rupp S, Dimmeler S. Single Nuclei Sequencing Reveals Novel Insights into the Regulation of Cellular Signatures in Children with Dilated Cardiomyopathy. Circulation. 2021 Feb 23. doi: 10.1161/CIRCULATIONAHA.120.051391. Online ahead of print.
  • Giannitsis E, Blankenberg S, Christenson RH, Frey N, von Haehling S, Hamm CW, Inoue K, Katus HA, Lee CC, McCord J, Möckel M, Chieh JTW, Tubaro M, Wollert KC, Huber K. Critical appraisal of the 2020 ESC guideline recommendations on diagnosis and risk assessment in patients with suspected non-ST-segment elevation acute coronary syndrome. Clin Res Cardiol. 2021 Feb 26. doi: 10.1007/s00392-021-01821-2. Online ahead of print.
  • De Smet MA, Lissoni A, Nezlobinsky T, Wang N, Dries E, Pérez-Hernández M, Lin X, Amoni M, Vervliet T, Witschas K, Rothenberg E, Bultynck G, Schulz R, Panfilov AV, Delmar M, Sipido KR, Leybaert L. Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability. J Clin Invest. 2021 Feb 23:137752. doi: 10.1172/JCI137752. Online ahead of print.
  • Andreadou I, Daiber A, Baxter GF, Brizzi MF, Di Lisa F, Kaludercic N, Lazou A, Varga ZV, Zuurbier CJ, Schulz R,Ferdinandy P. Influence of cardiometabolic comorbidities on myocardial function, infarction, and cardioprotection: Role of cardiac redox signaling. Free Radic Biol Med 166:33-52, 2021.
  • Dobersch S, Rubio K, Singh I, Günther S, Graumann J, Cordero J, Castillo-Negrete R, Huynh MB, Mehta A, Braubach P, Cabrera-Fuentes H, Bernhagen J, Chao CM, Bellusci S, Günther A, Preissner KT, Kugel S, Dobreva G, Wygrecka M, Braun T, Papy-Garcia D,Barreto G. Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation. Nat Commun 12:1072, 2021.
  • Dubrall D, Pflock R, Kosinska J, Schmid M, Bleich M, Himmerkus N, Offermanns S, Schwaninger M,Sachs B. Do dimethyl fumarate and nicotinic acid elicit common, potentially HCA(2) -mediated adverse reactions? A combined epidemiological-experimental approach. Br J Clin Pharmacol, 2021.
  • Kim WK, Bhumimuang K, Renker M, Fischer-Rasokat U, Möllmann H, Walther T, Choi YH, Nef H,Hamm CW. Determinants of paravalvular leakage following transcatheter aortic valve replacement in patients with bicuspid and tricuspid aortic stenosis. Eur Heart J Cardiovasc Imaging, 2021.
  • Montazeri L, Kowsari-Esfahan R, Pahlavan S, Sobat M, Rabbani S, Ansari H, Varzideh F, Barekat M, Rajabi S, Navaee F, Bonakdar S, Renaud P, Braun T,Baharvand H. Oxygen-rich Environment Ameliorates Cell Therapy Outcomes of Cardiac Progenitor Cells for Myocardial Infarction. Mater Sci Eng C Mater Biol Appl 121:111836, 2021.
  • Renker M, Kriechbaum SD, Schmidt SE, Larsen BS, Wolter JS, Dörr O, Fischer-Rasokat U, Kim WK, Liebetrau C, Bøttcher M, Nef H, Bauer T,Hamm CW. Prospective validation of an acoustic-based system for the detection of obstructive coronary artery disease in a high-prevalence population. Heart Vessels, 2021.
  • Sydykov A, Mamazhakypov A, Maripov A, Kosanovic D, Weissmann N, Ghofrani HA, Sarybaev AS,Schermuly RT. Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders. Int J Environ Res Public Health 18, 2021. review
  • Valgimigli M, Mehran R, Franzone A, Da Costa BR, Baber U, Piccolo R, Mcfadden EP, Vranckx P, Angiolillo DJ, Leonardi S, Cao D, Dangas GD, Mehta SR, Serruys PW, Gibson CM, Steg GP, Sharma SK, Hamm C, Shlofmitz R, Liebetrau C, Briguori C, Janssens L, Huber K, Ferrario M, Kunadian V, Cohen DJ, Zurakowski A, Oldroyd KG, Yaling H, Dudek D, Sartori S, Kirkham B, Escaned J, Heg D, Windecker S, Pocock S,Jüni P. Ticagrelor Monotherapy Versus Dual-Antiplatelet Therapy After PCI: An Individual Patient-Level Meta-Analysis. JACC Cardiovasc Interv 14:444-456, 2021.
  • Von Stillfried S, Acker T, Aepfelbacher M, Baretton G, Bülow RD, Bürrig KF, Holtherm HU, Jonigk D, Knüchel R, Majeed RW, Röhrig R, Wienströer J,Boor P. [Cooperative approach of pathology and neuropathology in the COVID-19 pandemic : German registry for COVID-19 autopsies (DeRegCOVID) and German network for autopsies in pandemics (DEFEAT PANDEMIcs)]. Pathologe:1-8, 2021.
  • Aravamudhan S, Türk C, Bock T, Keufgens L, Nolte H, Lang F, Krishnan RK, König T, Hammerschmidt P, Schindler N, Brodesser S, Rozsivalova DH, Rugarli E, Trifunovic A, Brüning J, Langer T, Braun T,Krüger M. Phosphoproteomics of the developing heart identifies PERM1 – An outer mitochondrial membrane protein. J Mol Cell Cardiol 154:41-59, 2021.
  • Daiber A, Steven S, Euler G,Schulz R. Vascular and cardiac oxidative stress and inflammation as targets for cardioprotection. Curr Pharm Des, 2021.
  • Hendgen M, Günther S, Schubert S,Löhnertz O. Ethephon Activates the Transcription of Senescence-Associated Genes and Nitrogen Mobilization in Grapevine Leaves (Vitis vinifera cv. Riesling). Plants (Basel) 10, 2021.
  • Rueschenbaum S, Ciesek S, Queck A, Widera M, Schwarzkopf K, Brüne B, Welsch C, Wedemeyer H, Zeuzem S, Weigert A,Lange CM. Dysregulated Adaptive Immunity Is an Early Event in Liver Cirrhosis Preceding Acute-on-Chronic Liver Failure. Front Immunol 11:534731, 2020.
  • Rappl P, Rösser S, Maul P, Bauer R, Huard A, Schreiber Y, Thomas D, Geisslinger G, Jakobsson PJ, Weigert A, Brüne B, Schmid T. Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression. Cell Death Dis 12(2):135, 2021.
  • Mas-Peiro S, Cremer S, Zeiher AM.  Clonal Hematopoiesis and Premature Menopause: Unexpected Liaison. Circulation. 143(5):424-426, 2021
  • Bertrams W, Griss K, Han M, Seidel K, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Vogelmeier CF, Schmeck B. Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection. Life Sci. 270:119158, 2021
  • Veeroju S, Kojonazarov B, Weiss A, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Novoyatleva T, Schermuly RT. Therapeutic Potential of Regorafenib-A Multikinase Inhibitor in Pulmonary Hypertension. Int J Mol Sci. 22(3):1502, 2021
  • Tombor LS, John D, Glaser SF, Luxán G, Forte E, Furtado M, Rosenthal N, Baumgarten N, Schulz MH, Wittig J, Rogg EM, Manavski Y, Fischer A, Muhly-Reinholz M, Klee K, Looso M, Selignow C, Acker T, Bibli SI, Fleming I, Patrick R, Harvey RP, Abplanalp WT, Dimmeler S. Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nat Commun. 12(1):681, 2021.
  • Aslam M, Gündüz D, Troidl C, Heger J, Hamm CW, Schulz R. Purinergic Regulation of Endothelial Barrier Function. Int J Mol Sci. 22(3):1207, 2021.
  • Wilkins MR. Personalized Medicine for Pulmonary Hypertension:: The Future Management of Pulmonary Hypertension Requires a New Taxonomy. Clin Chest Med. 42(1):207-216, 2021. review
  • Delgado Lagos FA, Elgheznawy A, Kyselova A, Meyer Zu Heringdorf D, Ratiu C, Randriamboavonjy V, Mann AW, Fisslthaler B, Siragusa M, Fleming I. Secreted modular calcium binding protein 1 binds/activates thrombin to account for platelet hyper-reactivity in diabetes. Blood, 2021.
  • Cetin R, Quandt E, Kaulich M. Functional Genomics Approaches to Elucidate Vulnerabilities of Intrinsic and Acquired Chemotherapy Resistance. Cells. 10(2):260, 2021. review
  • Reifart J, Schilling K, Hamm CW, Reifart N. Experience with the novel unifemoral parallel sheath technique in percutaneous intervention of chronic total coronary occlusions. Egypt Heart J. 73(1):14, 2021.
  • Chichareon P, van Klaveren D, Modolo R, Kogame N, Takahashi K, Chang CC, Tomaniak M, Yuan J, Xie L, Song Y, Qiao S, Yang Y, Guan C, Zurakowski A, van Geuns RJ, Sabate M, Ong PJ, Wykrzykowska JJ, Piek JJ, Garg S, Hamm C, Steg G, Vranckx P, Valgimigli M, Windecker S, Juni P, Onuma Y, Steyerberg E, Xu B, Serruys PW. Predicting 2-year all-cause mortality after contemporary PCI: Updating the logistic clinical SYNTAX score. Catheter Cardiovasc Interv, 2021.
  • Leonardi S, Branca M, Franzone A, McFadden E, Piccolo R, Jüni P, Vranckx P, Steg PG, Serruys PW, Benit E, Liebetrau C, Janssens L, Ferrario M, Zurakowski A, Diletti R, Dominici M, Huber K, Slagboom T, Buszman P, Bolognese L, Tumscitz C, Bryniarski K, Aminian A, Vrolix M, Petrov I, Garg S, Naber C, Prokopczuk J, Hamm C, Heg D, Windecker S, Valgimigli M. Comparison of Investigator-Reported and Clinical Event Committee-Adjudicated Outcome Events in GLASSY. Circ Cardiovasc Qual Outcomes, 2021.
  • Eichhorn F, Klotz LV, Kriegsmann M, Bischoff H, Schneider MA, Muley T, Kriegsmann K, Haberkorn U, Heussel CP, Savai R, Zoernig I, Jaeger D, Thomas M, Hoffmann H, Winter H, Eichhorn ME. Neoadjuvant anti-programmed death-1 immunotherapy by pembrolizumab in resectable non-small cell lung cancer: First clinical experience. Lung Cancer. 153:150-157, 2021.
  • Reifart J, Liebetrau C, Weferling M, Dörr O, Renker M, Bhumimuang K, Liakopoulos O, Choi YH, Nef H, Hamm CW, Kim WK. Single versus double use of a suture-based closure device for transfemoral aortic valve implantation. Int J Cardiol, 2021.

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