At the Institute for Vascular Signalling, Center for Molecular Medicine at the Faculty of Medicine, Goethe University, there is an open

PhD student position (E13 TV-G-U, 65%)

to study the role of one oxidative post-translational modifications (oxPTM) in the angiocrine regulation of vascular and cardiac homeostasis. The classification is based on the job characteristics of the collective agreement applicable to Goethe University (TV-G-U).

The position requires the following:

• Participation in a research project in a recently funded Collaborative Research Centre (SFB 1366) focusing on angiocrine signaling by endothelial cells under physiological and pathophysiological conditions in in vitro and in vivo
• The project also involves linking oxPTMs with metabolomic data (mass spectrometry based) with epigenetic regulation and changes in gene expressing (RNA and single cell sequencing).
• Collection of experimental data, analysis and documentation of results and preparation of material for publication.

We offer:

• A thematic high-level project in an internationally recognized group (ivs.uni-frankfurt.de), the DFG Cluster of Excellence “CardioPulmonary Institute” (www.cpi-online.de) and the German Center for Cardiovascular Research (DZHK.de).
• Rooms, housed in a modern research building, with state of the art facilities and analysis possibilities from integrative physiology to mass spectroscopy.
• Enrolment in an Integrated Research Training Group (that is part of SFB 1366) providing specific hands on training to perform cutting edge science in cardiovascular biology and mentoring for personal development.

Requirements:

• A completed, very good MSc in biology, biotechnology, molecular medicine or an equivalent discipline.
• An interest in discovering the molecular events underlying disease
• A background in metabolism and protein biochemistry.
• Good self-organization and ability to work in a team.
• Excellent written and spoken English

Applications with the usual documents (in a single PDF file) and the names and contact details of 3 referees should be submitted in electronic form within 4 weeks of the appearance of this advertisement to Prof. Dr. I. Fleming (fleming@vrc.uni-frankfurt.de).

The Institute for Vascular Signalling is a research institute that studies the biology of the vascular wall, heart and the factors that influence them during disease development. There is a particularly strong focus on the endothelial cells that are the inner most lining of the blood vessel and directly exposed to the flowing blood. We study substances generated by the endothelial cells themselves such as nitric oxide, hydrogen sulfide and mediators generated from polyunsaturated fatty acids by the sequential action of cytochrome P450 enzymes and the soluble epoxide hydrolase. A further series of projects addresses the impact of platelets and platelet-derived products as well as monocytes on the vascular wall and the heart and in the cardiovascular complications associated with diabetes. All of the projects have a translational biomedicine emphasis with the aim of improving on current cardiovascular disease therapy.
Collaborative networks: Projects housed at the Institute for Vascular Signalling belong to three different collaborative research centres (CRCs) including CRC 1039 “Disease-relevant signal transduction by fatty acid derivatives and sphingolipids”, CRC 1366 “Vascular Control of Organ Function” and CRC 1531 “Damage control by the stroma vascular compartment”. The institute also belongs to the Cardio Pulmonary Institute (a German Research Foundation funded Excellence Cluster) and the German Centre for Cardiovascular Research (DZHK).