The Cluster Project ENABLE – Unraveling mechanisms driving cellular homeostasis, inflammation and infection to enable new approaches in translational medicine is a newly established interdisciplinary research network which has been initiated jointly by the Goethe University Frankfurt, the Frankfurt Institute for Advanced Studies, the Fraunhofer Institute for Translational Medicine and Pharmacology, the Georg-Speyer-Haus and the Max Planck Institute of Biophysics. The network recently received funding from the State of Hessen and the positions for at the Institute for Biochemistry Il (Director: Prof. Dr. Dikic) will be available from April 1st, 2021 or later

8 postdoctoral scientists (m/f/d)

(E13 TV-G-U, full-time)

initially limited to two years. There is the possibility of subsequent employment. The salary grade is based on the job characteristics of the collective agreement applicable to Goethe University (TV-G-U).

The Cluster Project strives to unravel and understand selected pathogenic mechanisms and signaling pathways to identify disease-relevant critical targets for therapeutic intervention. The projects within the Cluster will focus on the areas of cellular homeostasis, infection and inflammation and cover the complete range from molecular mechanisms to translational clinical science and economic analysis. ENABLE is well embedded in the excellent research infrastructure at the participating universities and research institutions; all participating sites offer access to state-of-the-art technologies, wellequipped laboratories, a vibrant scientific exchange and an internationally competitive scientific training program. Details on the available projects can be obtained below from the respective group leaders; for overall information to the Cluster Project, candidates can visit www.enable-frankfurt.de.

We expect a completed scientific university degree in medicine, in natural sciences, computer science, mathematics or a comparable field. Furthermore, we expect a completed doctorate or comparable with in-depth specialist knowledge in biochemistry, chemical biology, cell biology, molecular biology, pharmacology, bioinformatics and systems biology (bioinformatics and programming skills are required) or biostatistics, mathematical modeling or the like.

A record of relevant peer-reviewed publications is mandatory. Candidates are highly motivated and enthusiastic to join the fast-moving and internationally highly competitive field and are characterized by good collaborative skills. Very good written and spoken English is expected. As part of ENABLE, we offer tailored interdisciplinary training to all researchers in the network, a framework of common scientific activities and a strong mentorship for future career development.

Applicants should choose their field of interest from the projects listed below and send their application not later than 30.03.2021 in a single pdf-file including cover letter, CV, scanned academic degrees, list of publications and two references with contact details to the responsible group leader.

Please do not send any original documents as the application documents will not be returned. Travel and application costs cannot be reimbursed.

Postdoctoral projects:

Cellular homeostasis (medicinal chemistry, chemical biology, structural biology)

Prof. Dr. Stefan Knapp, Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, knapp(at)pharmchem.uni-frankfurt.de

Infection (biochemistry, cell biology, molecular biology) Prof. Dr. Ivan Dikic, Institute of Biochemistry Il, Goethe University Frankfurt, dikic(at)biochem2.uni-frankfurt.de Infection (biochemistry, cell biology, molecular biology, proteomics)

Dr. Christian Münch, Institute of Biochemistry Il, Goethe University Frankfurt, ch.muench(at)em.uni-frankfurt.de Inflammation (molecular medicine)

Prof. Dr. Stefanie Dimmeler, Institute of Cardiovascular Regeneration, Goethe University Frankfurt, dimmeler(at)em.unifrankfurt.de

Inflammation (clinical pharmacology, reverse translation) Prof. Dr. Dr. Gerd Geißlinger, Institute for Clinical Pharmacology, Goethe University Frankfurt and Fraunhofer Institute for Translational Medicine and Pharmacology, geisslinger(at)em.uni-frankfurt.deInflammation (haematology, oncology)

Prof. Dr. Daniela Krause, Georg-Speyer-Haus and Goethe

University Frankfurt, krause(at)gsh.uni-frankfurt.de

Inflammation (pharmacy, cell biology)

Prof. Dr. Maike Windbergs, Institute of Pharmaceutical Technology and Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, windbergs(at)em.uni-frankfurt.de Across all areas: cellular homeostasis, infection & inflammation (theoretical biophysics)

Prof. Dr. Gerhard Hummer, Department of Theoretical Biophysics, Max Planck Institute of Biophysics, gerhard.hummer(at)biophys.mpg.de